IDG Consortium is a U54 program funded by the NIH Common Fund with the goal to shed light on areas of understudied targets. With this Common Fund support the aim The consortium encompasses three different groups: (1) Data and Resource Generating Centers (DRGC), (2) Knowledge Management Center (KMC), and (3) Resource Dissemination and Outreach Center (RDOC).
The focus for the DRGCs is on three protein families: G-protein coupled receptors, ion channels and protein kinases, for which there are lists of ‘understudied proteins’ (link to current list via Common Fund). Illumination of these proteins by DRGC are done by compound library screening (in vitro and in silico), antibody development, function and activation state profiling, and mouse expression profiling, to name a few processes. As data from these projects progress, IDG will be reporting the status on the availability of these newly developed resources (data and/or reagents) from the DRGCs.
The KMC work on gathering knowledge covering the entire human genome and expanding to model system, including GWAS studies, expression data, compound binding and patent information via ChEMBL. These are then sharing via the User Interface Portal called PHAROS. There are a number of different bioinformatics tools developed by KMC including TIN-x, Harmonizome, GEO2ENrichr, Enrichr, and Archs4.RDOC operate as a facilitator for the resources (reagents to data) generated by DRGC to be available to the general scientific community in a manner that is complaint with FAIR data sharing principles. This group organizes and coordinate consortium wide meetings. RDOC are open to co-host meetings with interested outside consortia. Please contact if interested. firstname.lastname@example.org
The various members of the IDG (Illuminating the Druggable Genome) consortium are sharing material from their grant submission including specific aims, scientific research strategy, timeline, milestones, and decision trees. Follow link to Scientific Grant Material to Preview.
Please email if interested in joining user lists or getting updates concerning the products and resources produced by the IDG members.