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Illuminating understudied druggable proteins using pan-cancer proteogenomics data

Bing Zhang, Ph.D.
Lester and Sue Smith Breast Cancer Baylor College of Medicine Professor Department of Moelcular and Human Genetics
Baylor College of Medicine


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Despite being the targets of 41% of approved drugs, kinases, G protein coupled receptors, and ion channels each have a number of family members about which very little is known. This project aims to integrate the recently available cancer proteogenomics data from the Clinical Proteomic Tumor Analysis Consortium (CPTAC) into the characterization of the understudied proteins in these families. Successful completion of the project will generate new computational methods and resources that can be used by the Illuminating the Druggable Genome (IDG) Consortium and the broad scientific community to generate hypotheses on the function of the understudied proteins for further experimental investigation.

NIH grant number: U01 CA271247