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Knowledge Management Center for Illuminating the Druggable Genome

Sorin I. Avram
Senior Researcher III
Computer Molecular Design
Institute of Chemistry Timisoara of Romanian Academy (ICTRA)
“Coriolan Drăgulescu” Institute of Chemistry
Timisoara, Jud. Timiș, Romania



Dr. Sorin Avram utilizes his background in pharmaceutical sciences together with programming skills to solve simple to complex problems including linking targets/genes to diseases/phenotypes. In addition his team collects data focusing on FDA new approved drugs, then integrates and organizes these into the existent database (e.g., DrugCentral), thereby verify and standardizing the pharmacological and regulatory information for active pharmaceutical ingredients and products from high standards resources. His team includes Dr. Ramona Curpan, Dr. Liliana Halip, and Dr. Alina Bora.

NIH grant number: 1U24 CA224370-01

KMC-ICTRA publications:

  1. DrugCentral 2021 supports drug discovery and repositioning. Avram S, Bologa CG, Holmes J, Bocci G, Wilson TB, Nguyen DT, Curpan R, Halip L, Bora A, Yang JJ, Knockel J, Sirimulla S, Ursu O, Oprea TI. Nucleic Acids Res. 2020 Nov 5:gkaa997. doi: 10.1093/nar/gkaa997. Online ahead of print. PMID: 33151287

  2. Off-Patent Drug Repositioning. Avram S, Curpan R, Halip L, Bora A, Oprea TI. J Chem Inf Model. 2020 Sep 15. doi: 10.1021/acs.jcim.0c00826. Online ahead of print. PMID: 32877182

  3. Novel drug targets in 2019. Avram S, Halip L, Curpan R, Oprea TI. Nat Rev Drug Discov. 2020 May;19(5):300. doi: 10.1038/d41573-020-00052-w. PMID: 32273590