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IDG Consortium

Sponsorship by NIH’s Common Fund has established the program called Illuminating Druggable Genome (IDG) Consortium with the aim of highlighting current knowledge of protein targets through integration of informatics tools, and further study the function of specific understudied targets in three main druggable protein families: G-protein coupled receptors, ion channels and protein kinases. This consortium consists of a network of (1) Data and Resource Generation Centers (DRGCs), each focusing their research on one of the three protein families, (2) the Knowledge Management Center (KMC) organizing data and integrated informatics tools across various resources to illuminate understudied protein targets, and (3) the Resource Dissemination and Outreach Center (RDOC) facilitating annotation and distribution of resources brought forth to shed light on to targets.

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Resource Dissemination And Outreach Center (RDOC)

The RDOC grant at U of Miami is led by Dr. Stephan Schürer. Work from his group will focus on dissemination of the resources generated from the DRGC by stewarding implementation of metadata standards for IDG and developing a Resource Management System (RMS) capable of a variety of data and resources. Dr. Larry Sklar heads the Management and Administration Core (MAC), which support and coordinates across the entire IDG Consortium. Dr. Tudor Oprea leads IDG outreach to other consortia or groups and develops training programs for PHAROS and informatics tools.

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Icahn School of Medicine at Mount Sinai (KMC-ISMMS)


The KMC at ISMMS is led by Dr. Avi Ma’ayan. Through systematic data integration and application of machine learning methods, the Ma'ayan Lab is filling knowledge gaps about the understudied IDG targets of interest. The Harmonizome which some of it is incorporated into Pharos, provides access to all integrated data and methods.

Recent IDG News

 

 

Knowledge Management Centers (NIH RFA-RM-16-024)

Main focus for KMC is to develop a platform to aggregate and integrate data from various sources to illuminate knowledge that together with machine learning algorithms and expert curation could inspire scientists to seek and explore new associations within the human proteome.

UNM Logo

T.I. Oprea @ UNM

KMC grant at UNM is led by Dr. Tudor Oprea and includes collaborations with Dr. Lars Juhl Jensen’s lab at NNFCPR and at EMBL-EBI with Dr. Andrew Leach as their Group Lead. Work from UNM includes the development of TCRD, the main database supporting Pharos, and appropriate visualization tools, such as TINx.

NCATS

NCATS

As a partner with the KMC, NCATS is developing and implementing PHAROS as the User Interface Portal to access all the integrated data, metadata and annotation collected into TCRD and via tools from ISMMS. 

EMBL

A. Leach @ EMBL

EMBL-EBI has developed tools for automated extraction and expert curation of medicinal chemistry data. The group led by A. Leach has extracted pertinent target-chemical pairs from the patent literature and late-stage drug development, as well as the clinical candidate literature.

 

NNFCPR

L.J. Jensen @ NNFCPR

Work by Dr. Lars Juhl Jensen has resulted in improved text-mining technology that is applied to scientific literature for scoring how well studied each target protein may be and to support target prioritization. This text-mining platform also helps provide tissue and disease associations for the targets.

ISMMS

A. Ma'ayan @ ISMMS

The KMC at ISMMS is led by Dr. Avi Ma’ayan. Through systematic data integration and application of machine learning methods, the Ma'ayan Lab is filling knowledge gaps about the understudied IDG targets of interest. The Harmonizome which some of it is incorporated into Pharos, provides access to all integrated data and methods.

IDG Events

Events

MARCH 2018 

March 13-14, 2018: IDG Phase 2 Face-to-Face meeting at NIH campus.  

DRGC – Data and Resource Generation Centers (NIH RFA-RM-16-026)

The objective of the DRGCs is to further illuminate understudied targets in the three main druggable protein families: G-protein coupled receptors, ion channels, and protein kinases. Their experimental workflows incorporate multiple robust assays on cellular basis of target action and extends to animal models. Data and Resources generated are disseminated via RDOC.

UCSF

B.L. Roth @ UNC
B. Shoichet @UCSF

GPCR

Collaborative work by Dr. Bryan Roth and Dr. Brian Shoichet focuses on illuminating the druggable GPCR-ome by a two-pronged approach of empirical screening of drugs followed by computational screening against modeled structures of the GPCR to produce optimized lead compounds. Their work has led to discovery of molecule “ogerin” binding to previously orphaned GPR68.

 

UCSF

M.T. McManus @ UCSF

Ion Channels

Dr. Michael T. McManus together with Dr. Lily Jan leads a group researchers from UCSF and UCD focused on illuminating Ion Channels by utilizing CRISPR technology to map expression profiles, assess channel activities, develop antibodies, and generate new mouse lines.

IDG

G.L. Johnson @ UNC

Kinases

Dr. Gary L. Johnson has established a network of collaborators; Dr. Shawn Gomez (UNC), Dr. Ben Major (UNC), Dr. Tim Willson (SGC), Dr. Reid Townsend (WU), and Dr. Peter Sorger (HMS), to tackle the illumination of function of the understudied druggable kinome. Their work includes technologies of Multiplex Inhibitor Beads (MIB) / Mass Spectrometry (MS) to identify kinase activation status in response to perturbants, and applies results to model cell lines and patient derived xenographs.

 

RDOC - Resource Dissemination and Outreach Center (NIH RFA-RM-16-025)

RDOC serves as a hub for exposing the outcomes from the IDG be it via dissemination of resources and data generated by the DRGC or training public on utility of knowledge accumulated by the KMC. The mission for RDOC is to highlight and expose the works by IDG in a manner that is enduring and fruitful for further scientific discovery.


miami

S.C. Schürer @ UofMiami

The RDOC grant at U of Miami is led by Dr. Stephan Schürer. Work from his group will focus on dissemination of the resources generated from the DRGC by stewarding implementation of metadata standards for IDG and developing a Resource Management System (RMS) capable of a variety of data and resources.

 

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T.I. Oprea & L.A. Sklar @ UNM

The RDOC collaboration extends to UNM. Dr. Larry Sklar heads the Management and Administration Core (MAC), which support and coordinates across the entire IDG Consortium. Dr. Tudor Oprea leads IDG outreach to other consortia or groups and develops training programs for PHAROS and informatics tools.

 

KMC Events

News/Events