Knowledge Management Center for Illuminating the Druggable Genome

Ewy A. Mathé
Director of Informatics
Division of Preclinical Innovation
DPI Cores
National Center for Advancing Translational Sciences
National Institutes of Health


Pharos: @idg_pharos


As a partner with the KMC, NCATS is developing and implementing PHAROS as the User Interface Portal to access all the integrated data, metadata and annotation collected into TCRD and via tools from ISMMS. Queries across all human proteins can be carried out based on Target Development Levels stages of knowledge for protein targets from most known (Tclin) to least known (Tdark), tissue expression, chemical tools, Novelty score, etc.

NIH grant number: 1U24 CA224370-01 and ZIA TR000057

KMC-NCATS publications:

  1. How to Illuminate the Druggable Genome Using Pharos. Sheils T, Mathias SL, Siramshetty VB, Bocci G, Bologa CG, Yang JJ, Waller A, Southall N, Nguyen DT, Oprea TI. Curr Protoc Bioinformatics. 2020 Mar;69(1):e92. doi: 10.1002/cpbi.92. PMID: 31898878
  2. Pharos: Collating protein information to shed light on the druggable genome. Nguyen DT, Mathias S, Bologa C, Brunak S, Fernandez N, Gaulton A, Hersey A, Holmes J, Jensen LJ, Karlsson A, Liu G, Ma'ayan A, Mandava G, Mani S, Mehta S, Overington J, Patel J, Rouillard AD, Schürer S, Sheils T, Simeonov A, Sklar LA, Southall N, Ursu O, Vidovic D, Waller A, Yang J, Jadhav A, Oprea TI, Guha R. Nucleic Acids Res. 2017 Jan 4;45(D1):D995-D1002. doi: 10.1093/nar/gkw1072. Epub 2016 Nov 29. PMID: 27903890, PMCID: PMC5210555  
  3. Drug target ontology to classify and integrate drug discovery data. Lin Y, Mehta S, Küçük-McGinty H, Turner JP, Vidovic D, Forlin M, Koleti A, Nguyen DT, Jensen LJ, Guha R, Mathias SL, Ursu O, Stathias V, Duan J, Nabizadeh N, Chung C, Mader C, Visser U, Yang JJ, Bologa CG, Oprea TI, Schürer SC. J Biomed Semantics. 2017 Nov 9;8(1):50. doi: 10.1186/s13326-017-0161-x. PMID: 29122012, PMCID: PMC5679337