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News: Nucleic Acid Research Database issue features IDG digital resources.


2021-05-18: Two IDG-associated R03 awardees will share outcomes from their IDG grants at the final session of the IDG e-Symposium Series on May 18th–Dr. Thomas Green, PhD, University of Texas Medical Branch, "GPR12 in the nucleus accumbens and addiction: electrophysiology and behavior" andDr. Daniel G. Isom, PhD, University of Miami Miller School of Medicine, "Illuminating how dark GPCRs detect protons". To register visit this link: https://idg-e-symposium-series-may182021.eventbrite.com |Read More|


2021-05-04: The 5th Session of the IDG e-Symposium Series comes with a force on May 4th with two talks on Informatics Tools – one by Dr. Paul W. Sternberg, PhD, CalTech, "Curating, integrating and presenting information about model organisms at the Alliance of Genome Resources" and one by Dr. Lincoln Stein, MD PhD, OICR and co-PI of Reactome, "Guilt by Association: A Few Tricks for Finding and Characterizing Cancer-Associated Genes". To register visit this link: https://idg-e-symposium-series-may042021.eventbrite.com |Read More|


2021-04-20: Session 4 of the IDG e-Symposium Series occurs Tuesday, April 20th, 2021 with two talks on Ion Channels by Dr. Srinivas Niranj Chandrasekaran, Broad Institute, "Accelerating drug discovery with the power of microscopy" and Dr. Stefan Feske, New York University School of Medicine, "Identification of novel ion channels and transporters in immune cells". To register visit this link: https://idg-e-symposium-series-april202021.eventbrite.com |Read More|


2021-04-06: Session 3 of the IDG e-Symposium Series occurs Tuesday, April 6th, 2021. It will showcase two talks on GPCR by invited speaker, Dr. Aashish Manglik, PhD, University of California San Francisco, "Fishing with new bait: biochemical approaches to interrogate orphan GPCR function" and and by IDG speaker, Dr. Can Cao, DRGC-GPCR, "Structural and functional study of orphan receptor". To register visit this link: https://idg-e-symposium-series-april062021.eventbrite.com |Read More|


2021-03-30: The continuation of the IDG e-Symposium Series with Session 2 will take place on Tuesday, March 30th, 2021. It will showcase two talks on kinases by Invited speaker: Dr. Martin Golkowski, University of Washington, "Targeting Phenotypic Transitions to Overcome Cancer Metastasis and Therapy Resistance" and IDG speaker: Dr. Gary Johnson, PI for DRGC-Kinase, "Plasticity of the Human Kinome Responding to Targeted Kinase Inhibition". Registration: click this link https://idg-e-symposium-series-march302021.eventbrite.com/ |Read More|


2021-03-16: The inaugural session of the IDG e-Symposium Series will take place on Tuesday, March 16th, 2021. It showcase two talks on the theme of Informatics platforms and Drug Discovery. Invited speaker: Dr. Ian Dunham, Director of Open Targets at EMBL-EBI, "Identifying and prioritising drug targets with the Open Targets Platform and Open Targets Genetics". IDG speaker: Dr. Tudor Oprea, PI for KMC and RDOC, "Illuminating the Druggable Genome: Drugs, Targets, Phenotypes and Diseases". Register here: https://idg-e-symposium-series-march162021.eventbrite.com |Read More|


TCRD and Pharos 2021: mining the human proteome for disease biology.

Two resources produced from these efforts are: The Target Central Resource Database (TCRD) (http://juniper.health.unm.edu/tcrd/) and Pharos (https://pharos.nih.gov/), a web interface to browse the TCRD. The ultimate goal of these resources is to highlight and facilitate research into currently understudied proteins, by aggregating a multitude of data sources, and ranking targets based on the amount of data available, and presenting data in machine learning ready format. Since the 2017 release, both TCRD and Pharos have produced two major releases, which have incorporated or expanded an additional 25 data sources. Recently incorporated data types include human and viral-human protein-protein interactions, protein-disease and protein-phenotype associations, and drug-induced gene signatures, among others. These aggregated data have enabled us to generate new visualizations and content sections in Pharos, in order to empower users to find new areas of study in the druggable genome.


Nucleic Acid Research Database issue features IDG digital resource: Drugcentral.org


New additions to DrugCentral.org include a set of pharmacokinetic properties for ∼1000 drugs, and a sex-based separation of side effects, processed from FAERS (FDA Adverse Event Reporting System); as well as a drug repositioning prioritization scheme based on the market availability and intellectual property rights forFDA approved drugs. In the context of the COVID19 pandemic, we also incorporated REDIAL-2020, a machine learning platform that estimates anti-SARS-CoV-2 activities, as well as the 'drugs in news' feature offers a brief enumeration of the most interesting drugs at the present moment. The full database dump and data files are available for download from the DrugCentral web portal.


Nucleic Acid Research Database issue features IDG digital resource: The Dark Kinase Knowledgebase


Here, we describe a data resource, the Dark Kinase Knowledgebase (DKK; https://darkkinome.org), that is specifically focused on providing data and reagents for these understudied kinases to the broader research community. Supported through NIH’s Illuminating the Druggable Genome (IDG) Program, the DKK is focused on data and knowledge generation for 162 poorly studied or ‘dark’ kinases. Types of data provided through the DKK include parallel reaction monitoring (PRM) peptides for quantitative proteomics, protein interactions, NanoBRET reagents, and kinase-specific compounds.


2020-11-30: Publication of IDG Newsletter, vol 15: link to page


2020-10-30: Publication of IDG Newsletter, vol 14: link to page


2020-10-26: ATOM-IDG Symposium Series: The goal for this outreach event is to explore collaborative activities via a joint symposium that would promote development of drugs from IDG probes. ATOM (Accelerating Therapeutics for Opportunities in Medicine) is a consortium of National Labs, Biotech/Pharma Companies and UCSF. The objective of ATOM is to transform drug discovery from experiment-driven, sequential, and high-failure to computation-driven, integrated and patient-centric. |Read More|


2020-09-30: Publication of IDG Newsletter, vol 13: link to page


2020-09-24: NIH recently announced the eight recipients of supplements via NOT-TR-20-008: Notice of Special Interest for HEAL Initiative: Request for Administrative Supplements to Existing Grants for Identification and Validation of New Pain and Opioid Use Disorder Targets within the Understudied Druggable Genome.


2020-09-10: IDG OUTREACH Meeting UNC: This symposium is aimed toward participants interested in target selection in drug discovery, expansion of protein function, development of experimental and informatics approaches to understanding proteins, as well as potential collaborators from academia, industry and not-for-profit institutes. This symposium was held virtually on Thursday, September 10th and Friday September 11th, 2020. Initially this meeting was scheduled for May 4-5, 2020. |Read More|


2020-09-01: NIH have announced the second round of IDG associated R03’s - ‘Pilot Projects Investigating Understudied G Protein-Coupled Receptors, Ion Channels, and Protein Kinases (R03 Clinical Trial Not Allowed)’ - RFA-RM-19-011: This time there are 17 R03 awardees. Congratulations!


2020-08-31: Publication of IDG Newsletter, vol 12: link to page


2020-07-31: Publication of IDG Newsletter, vol 11: link to page


2020-06-30: Publication of IDG Newsletter, vol 10: link to page


2020-05-29: Publication of IDG Newsletter, vol 9: link to page


2020-05-19: NIH announces a Request for Information (RFI): Input on Improvements to the Illuminating the Druggable Genome (IDG) Program’s Digital Resources - NOT-RM-20-018.  The feedback requested concerning IDG’s search engine Pharos and our program’s website DruggableGenome.net.  Due date for responses is July 20, 2020.


2020-04-22: NIH announces funding opportunity for ‘Pilot Projects Investigating Understudied G Protein-Coupled Receptors, Ion Channels, and Protein Kinases (R03 Clinical Trial Not Allowed)’ – RFA-RM-20-019. This is a reissue of RFA-RM-19-011. Application due date is July 15, 2020.


2020-04-22: Publication of IDG Newsletter, vol 8: link to page


2020-02-11: IDG held their annual consortium wide Face-to-Face meeting in Arlington, VA on February 11-12, 2020, with special invitations to the IDG associate R03 awardees.


2020-02: Publication of IDG Newsletter, vol 7: link to page


2020-01-22: KMC at UNM hosted an IDG hackathon in Albuquerque, NM on January 22-23, 2020 addressing informatics tools and methods for the IDG community and included external invitations to members of the Monarch Initiative and RCSB Protein Data Bank.


2020-01: Publication of IDG Newsletter, vol 6: link to page


2019-11-15: Finding Targets for Drug Discovery - A joint symposium hosted by Open Targets and Illuminating the Druggable Genome consortium highlighting their work to expand knowledge and experimental data to enable new targets in drug discovery.
|Read More| Registration was made via Eventbrite: see here . For a pdf of the public summary, see here.


2019-11: Publication of IDG Newsletter, vol 5: link to page


2019-10: Publication of IDG Newsletter, vol 4: link to page


2019-09: Publication of IDG Newsletter, vol 3: link to page


2019-09-01: NIH have announced 16 awardees for the IDG associated R03’s - ‘Pilot Projects Investigating Understudied G Protein-Coupled Receptors, Ion Channels, and Protein Kinases (R03 Clinical Trial Not Allowed)’ - RFA-RM-18-021: Congratulations!  This is Round 1 of IDG associated R03 awardees.


2019-08: Publication of IDG Newsletter, vol 2: link to page


2019-07: Publication of IDG Newsletter, vol 1: link to page


2019-07-10:  NIH announces funding opportunity for ‘Pilot Projects Investigating Understudied G Protein-Coupled Receptors, Ion Channels, and Protein Kinases (R03 Clinical Trial Not Allowed)’ – RFA-RM-19-011. This is a reissue of RFA-RM-18-021.


2019-07-01: NIH announces special funding opportunity via Administrative Supplements to Existing NIH Grant and Cooperative Agreements, ‘Notice of Special Interest (NOSI): Availability of Administrative Supplements for Enhancing Utility and Usage of Common Fund Data Sets’ – NOT-RM-19-009.


2019-05-20: NIH have announced all the awardees for the CEIT - Cutting Edge Informatics Tools for Illuminating the Druggable Genome (U01) - RFA-RM-18-011: Dr. Kannan (UGA), Dr. Robinson (JAX), Dr. Wu (OHSU). These three groups are our newest members to the IDG consortium.  Congratulations!


2019-05-10: Winners are announced for the IDG-DREAM Drug Kinase Binding Prediction Challenge (www.synapse.org/drugkinasechallenge). The top performers ‘Team QED’, ‘Team AI Winter is Coming’, and ‘DMIS_DK’ will be presenting their work at the RECOMB/ISCB RSG conference - https://www.iscb.org/recomb-regsysgen2019, held Nov. 4-6, 2019 in New York City, NY.


2019-02-26: IDG held their annual Face-to-Face meeting in Arlington, VA on February 26-27, 2019.  Here is a link to the public summary for this meeting: link to pdf.


2018-12-10: PLOS Biology Commentary from IDG PI’s, https://doi.org/10.1371/journal.pbio.3000067


2018-11-15: Deadline for Round 1 of IDG-DREAM Drug Kinase Binding Prediction Challenge https://www.synapse.org/#!Synapse:syn15667962/wiki/583305


2018-11-07: Dr. Bryan Roth gave the Presidential Special Lecture entitled "From Salvia Divinorum to LSD: Toward a Molecular Understanding of Psychoactive Drug Actions" at the annual meeting for Society for Neurosciences in San Diego, CA on Nov 7 2018 -https://www.sfn.org/Meetings/Neuroscience-2018/Sessions-and-Events/Scientific-Program/Lectures"link to information site


2018-10-24: NIH announces funding opportunities via two different mechanisms: SBIR: ‘Commercializing Understudied Proteins from the Illuminating the Druggable Genome Project (IDG) (R43/R44 Clinical Trial Not Allowed)’ - PA-19-034 and STTR: ‘Commercializing Understudied Proteins from the Illuminating the Druggable Genome Project (IDG) (R41/R42 Clinical Trial Not Allowed)’ - PA-19-033.


2018-10-16: BIOINFORMATICS BOOTCAMP: INFORMATICS IN DISEASE BIOLOGY AND DRUG DISCOVERY, Tuesday, October 16 - 4:30-6:30pm. Hands-on worskhop to access, visualize and analyse IDG-specific data -- requires additional registration fee and there will be a limited number of attendees (NAVBO2018) Newport, RI - link to information site


2018-10-01: Launch of IDG-DREAM Drug Kinase Binding Prediction Challenge (https://www.synapse.org/#!Synapse:syn15667962/wiki/583305), with press release from FIMM (https://www.fimm.fi/en/news/1538461918)


2018-08-23: IDG Outreach meeting with BAGIM (Boston Area Group for Informatics and Modeling) at Harvard University, covering presentation from IDG members. |Read More|


2018-08-22: Symposium entitled “Move Away from the Lamppost & Find Druggable Targets” at ACS Fall 2018 National Meeting in Boston, MA, organized by Tudor Oprea and Rajarshi Guha |Read More|


2018-07-20: NIH announces funding opportunity for ‘Pilot Projects Investigating Understudied G Protein-Coupled Receptors, Ion Channels, and Protein Kinases (R03 Clinical Trial Not Allowed)’ - RFA-RM-18-021.


2018-03-13: IDG Consortium Kick-off meeting was held on NIH Campus in the Natcher Building on March 13-14, 2018.  The full IDG consortium, at this time, includes:

  • 3 DRGC awardees: GPCR focused: Dr. Roth (UNC), Kinase focused: Dr. Johnson (UNC), Ion Channel focused: Dr. McManus (UCSF)
  • 2 KMC awardees: Dr. Ma’ayan (ISMMS), Dr. Oprea (UNM)
  • 1 RDOC awardee: Dr. Schürer (UMiami)

2018-02-03: Dr. Rajarshi Guha, (KMC-NCATS), presented as an 2018 SLAS finalist with a talk entitled "Pharos – A Torch to Use in Your Journey In the Dark Genome" at 2018 Annual SLAS meeting in San Diego, CA Feb 3-7, 2018. - link to information site