IDG Understudied Proteins, October 2, 2018
Goal of IDG
The goal of the Illuminating the Druggable Genome (IDG) Program is to improve our understanding of the properties and functions of proteins that are currently not well studied within commonly drug-targeted protein families. IDG began in 2014 and received funding for a three year pilot phase. The pilot phase of the program developed a website, called Pharos, that integrates information about understudied proteins so that researchers everywhere can easily access it, catalyzing their own research and helping them find new proteins that may be of interest. In addition, IDG supported researchers developed technologies to enable the study of understudied druggable proteins in a high throughput manner. During 2017, IDG was approved for a second stage of funding, called the Implementation Phase. During the Implementation Phase, IDG aims to expand the informatics tools developed in the Pilot Phase, elucidate the function of understudied proteins from three key druggable protein familes (GPCRs, ion channels, and kinases), and disseminate the IDG-generated resources to the greater scientific community.
The implementation phase of the IDG program will focus on elucidating the function of understudied proteins from three protein families; non-olfactory GPCRs, ion channels, and protein kinases. This page lists protein targets that will be the initial focus of the implementation phase of the IDG program. These lists were generated using bibliometric measures coupled with a lack of R01 funding and were updated on October 2, 2018.