Executive Summary
IDG Outreach meeting at UNC
September 10-11, 2020
Virtual, via Zoom Teleconference
Meeting Agenda with links to YouTube presentations:
Thursday, September 10 6:00-8:00 PM: PLENARY SESSION –
YouTube Link
“Protein Kinase C Unbalanced: Loss-of-function vs gain-of-function in
disease”
Alexandra Newton, PhD
Department of Pharmacology, University of California, San Diego
Friday, September 11 9:00 AM-5:00 PM: Symposium
9:00-9:10 AM: Welcome (Bryan Roth, MD, PhD) (15 min)
9:10-9:20 AM: Understudied Kinome Introduction (Gary Johnson, PhD) (10 min)
9:20-9:40 AM: “Chemoproteomic approaches to accelerate kinase degrader
development”
Fleur M Ferguson, PhD – DRGC-Kinase
Dana Farber Cancer Institute and Harvard University
9:40-10:00 AM: “Evolutionary clues to dark kinase functions”
Natarajan Kannan, PhD – CEIT-UGA – YouTube Link
Department of Biochemistry and Molecular Biology, University of Georgia
10:00-10:20 AM: “Functional integration of understudied kinases into
established
signaling pathways using quantitative omics data”
Robert Sprung, PhD – DRGC-Kinase – Proteomics Laboratory
Washington University School of Medicine
Michael P East, PhD – DRGC-Kinase - YouTube Link
Department of Pharmacology, University of North Carolina School of Medicine
10:20-10:50 AM: Panel and Live Q&A with speakers (30 min)
10:50-11:05 AM: Break (15 min)
11:05-11:15 AM: Introduction to understudied Ion Channels (Michael T. McManus,
PhD) (10
min)
11:15-11:35 AM: “Illuminating the dark channelome”
Olga Gulyaeva, PhD – DRGC-Ion Channel – YouTube Link
School of Medicine, University of California, San Francisco
11:35-11:45 AM: Panel and Live Q&A with speakers (10 min)
11:45-1:15 PM: Lunch with Breakout sessions (BioInformatics / GPCR/ Ion Channel / Kinase) (1.5 hr)
1:15-1:25 PM: Introduction to Informatics (Tudor Oprea, MD, PhD) (10 min)
1:25-1:45 PM: “Integration of Biomedical Knowledge Graph Mining and
Generative Neural
Nets for Drug Discovery”
Alexander Tropsha, PhD – YouTube
Link
Eshelman School of Pharmacy, University of North Carolina
1:45-2:05 PM: “FRASE-bot, an AI-powered Tool for Data-driven Drug
Discovery on Orphan
Targets”
Dmitry Kireev, PhD – YouTube
Link
Eshelman School of Pharmacy, University of North Carolina
2:05-2:25 PM: “Structure-based deorphanization, and the computational
infrastructure that
supports it”
John Irwin, PhD – DRGC-GPCR – YouTube
Link
School of Pharmacy, University of California, San Francisco
2:25-2:45 PM: “Data science to illuminate the dark genome”
Tudor Oprea, MD, PhD – KMC, RDOC – YouTube Link
Translational Informatics Division, University of New Mexico
2:45-3:15 PM: Panel and Live Q&A with speakers (30 min)
3:15-3:30 PM: Break (15 min)
3:30-3:45 PM: Introduction to understudied GPCRs (Bryan Roth, MD, PhD) (15
min)
3:45-4:05 PM: "Insights into ligand mechanisms for “biasing” G
protein-coupled
receptor signaling”
Laura Wingler, PhD – YouTube
Link
School of Medicine, Duke University
4:05-4:25 PM: “New CRISPR-based technologies for exploring the dark
GPCRome”
Daniel Isom, PhD – YouTube
Link
Department of Molecular and Cellular Pharmacology, University of Miami
4:25-4:45 PM: Panel and Live Q&A with speakers (20 min)
4:45-5:00 PM: Wrap-up (Roth, McManus, Johnson, Oprea)
About this Event
IDG OUTREACH MEETING at UNC
Plenary session and all-day symposium hosted at University of North Carolina, Chapel
Hill, highlighting
the work by the Illuminating the Druggable Genome consortium focusing on three target
families (GPCRs,
Ion Channels, Kinases) and informatics. This meeting will now be held online.
Dates: Thursday, September 10th and Friday, September 11th, 2020
Venue: Virtual/Online meeting – Zoom information will be sent
out closer to
date
Plenary Session on Sept. 10th
All-day Symposium on Sept. 11th
Application
opens: Monday, January 13, 2020 Application deadline: Monday, August 3rd,
2020
Contact: RDOC idg.rdoc@gmail.com
Overview:
IDG consortium are partnering together with member groups at UNC to host an open plenary
session and an
all-day symposium to share their progress on investigating proteins and their impact on
diseases and
phenotypes. Illuminating the Druggable Genome (IDG) is a NIH founded consortium that
aims to highlight
new, previously understudied targets within the human genome with the goal of furthering
scientific
discovery for improving human health. The IDG consortium is made up of experimental
groups working in
three major protein families: GPCRs, Ion Channels, and Kinases, along with informatics
groups managing
knowledge and developing tools for improving data analysis and target prioritization. In
the agenda,
speakers from the IDG consortium have been noted to their IDG grant affiliations;
DRGC-Data and Resource Generating Center,
KMC-Knowledge Management
Center, RDOC-Resource Dissemination and Outreach Center,
CEIT-Cutting
Edge Informatics Tools.
Audience:
This symposium is aimed toward participants interested in target selection in drug
discovery, expansion
of protein function, development of experimental and informatics approaches to
understanding proteins,
as well as potential collaborators from academia, industry and not-for-profit
institutes.
How to attend
Please register to attend this virtual/online meeting via Eventbrite site, found here (link to Evenbrite).
This event is free for attendees. The Zoom meeting details will be sent out to all
registered
individuals closer to the meeting date.
**Updated March 12, 2020: In light of the COVID-19 situation, this meeting has been postponed from it’s original date of May 4-5, 2020 to tentative date of September 10-11, 2020.**
**Update June, 2020: This meeting will be held as a virtual meeting. Registration is required in order to receive Zoom meeting details.
Agenda (please note all times listed are Eastern Daylight Time):
Thursday, September 10 6:00-8:00 PM: PLENARY SESSION
“Protein Kinase C Unbalanced: Loss-of-function vs gain-of-function in
disease”
Alexandra Newton, PhD
Department of Pharmacology, University of California, San Diego
Friday, September 11 9:00 AM-5:00 PM: Symposium
9:00-9:10 AM: Welcome (Bryan Roth, MD, PhD) (15 min)
9:10-9:20 AM: Understudied Kinome Introduction (Gary Johnson, PhD) (10 min)
9:20-9:40 AM: “Chemoproteomic approaches to accelerate
kinase degrader
development”
Fleur M Ferguson, PhD – DRGC-Kinase (20 min)
Dana Farber Cancer Institute and Harvard University
Natarajan Kannan, PhD – CEIT-UGA
Department of Biochemistry and Molecular Biology, University of Georgia
10:00-10:20 AM: “Functional integration of understudied
kinases into
established signaling pathways using quantitative omics data”
(20 min)
Robert Sprung, PhD – DRGC-Kinase
Proteomics Laboratory, Washington University School of Medicine
Michael P East, PhD – DRGC-Kinase
Department of Pharmacology, University of North Carolina School of Medicine
10:20-10:50 AM: AM: Panel and Live Q&A with speakers (30 min)
10:50-11:05 AM: Break (15 min)
11:05-11:15 AM: Introduction to understudied Ion Channels (Michael T. McManus, PhD) (10 min)
11:15-11:35 PM: “Illuminating the dark channelome” (20 min)
Olga Gulyaeva, PhD – DRGC-Ion Channel
School of Medicine, University of California, San Francisco
11:15-11:45 PM: : Panel and Live Q&A with speakers (10 min)
11:45-1:15 PM: Lunch with Breakout sessions (BioInformatics / GPCR/ Ion Channel /
Kinase) (1.5 hr)
1:15-1:25 PM: Introduction to Informatics (Tudor Oprea, MD, PhD) (10 min)
1:25-1:45 PM: “Integration of Biomedical Knowledge Graph
Mining and
Generative Neural Nets for Drug Discovery” (20 min)
Alexander Tropsha, PhD
Eshelman School of Pharmacy, University of North Carolina
1:45-2:05 PM: “FRASE-bot, an AI-powered Tool for Data-driven Drug Discovery on
Orphan
Targets” (20 min)
Dmitry Kireev, PhD
Eshelman School of Pharmacy, University of North Carolina
2:05-2:25 PM: “Structure-based deorphanization, and the
computational
infrastructure that supports it” (20 min)
John Irwin, PhD – DRGC-GPCR
School of Pharmacy, University of California, San Francisco
2:25-2:45 PM: “Data science to illuminate the dark genome” (20 min)
Tudor Oprea, MD, PhD – KMC, RDOC
Translational Informatics Division, University of New Mexico
2:45-3:15 PM: Panel and Live Q&A with speakers (30 min)
3:15-3:30 PM: Break (15 min)
3:30-3:45 PM: Introduction to understudied GPCRs (Bryan Roth, MD, PhD) (15 min)
3:45-4:05 PM: "Insights into ligand mechanisms for
“biasing” G protein-coupled receptor signaling” (20 min)
Laura Wingler, PhD
School of Medicine, Duke University
4:05-4:25 PM: New CRISPR-based technologies for exploring the dark GPCRome” (20 min)
Daniel Isom, PhD
Department of Molecular and Cellular Pharmacology, University of Miami
4:25-4:45 PM: Panel and Live Q&A with speakers (20
min)
4:45-5:00 PM:
Wrap-up (Roth, McManus, Johnson, Oprea)