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IDG OUTREACH Meeting UNC      Register Here


Dates

Monday May 4th and Tuesday May 5th, 2020

Venues

University of North Carolina, Chapel Hill
Plenary Session on May 4th: 1131 Bioinformatics Building
All-day Symposium on May 5th: Bondurant Hall G100

Application opens

Monday, January 13, 2020

Registration deadline

Friday, April 3rd, 2020

Contact:

RDOC: idg.rdoc@gmail.com

Overview

IDG consortium are partnering together with member groups at UNC to host an open plenary session and an all-day symposium to share their progress on investigating proteins and their impact on diseases and phenotypes. Illuminating the Druggable Genome (IDG) is a NIH founded consortium that aims to highlight new, previously understudied targets within the human genome with the goal of furthering scientific discovery for improving human health. The IDG consortium is made up of experimental groups working in three major protein families: GPCRs, Ion Channels, and Kinases, along with informatics groups managing knowledge and developing tools for improving data analysis and target prioritization. In the agenda, speakers from the IDG consortium have been noted to their IDG grant affiliations; DRGC-Data and Resource Generating Center, KMC-Knowledge Management Center, RDOC-Resource Dissemination and Outreach Center, CEIT-Cutting Edge Informatics Tools.

Audience

This symposium is aimed toward participants interested in target selection in drug discovery, expansion of protein function, development of experimental and informatics approaches to understanding proteins, as well as potential collaborators from academia, industry and not-for-profit institutes.

How to attend

Please register to attend this meeting via Eventbrite site, HERE. This event is free for attendees. No federal funds will be spent on food.

Agenda: Monday, May 4

6:00-8:00 PM: PLENARY SESSION with Buffet meal

UNC, Chapel Hill, 1131 Bioinformatics Building

“Protein Kinase C Unbalanced: Loss-of-function vs gain-of-function in disease"

Alexandra Newton, PhD

Department of Pharmacology, University of California, San Diego

Tuesday, May 5

8:30 AM-5:00 PM: SYMPOSIUM UNC, Chapel Hill, Bondurant Hall G100

8:30-9:00 AM: Breakfast buffet with networking opportunities

9:00-9:15 AM: Welcome (Bryan Roth, MD, PhD)

9:15-9:25 AM: Understudied Kinome Introduction(Gary Johnson, PhD)

  • 9:25-9:50 AM: “Chemoproteomic approaches to accelerate kinase degrader development” Fleur M Ferguson, PhD – DRGC-Kinase, Dana Farber Cancer Institute and Harvard University
  • 9:55-10:30 AM: “Evolutionary clues to dark kinase functions” Natarajan Kannan, PhD – CEIT-UGA, Department of Biochemistry and Molecular Biology, University of Georgia
  • 10:30-11:00 AM: “Functional integration of understudied kinases into established signaling pathways using quantitative omics data” Robert Sprung, PhD – DRGC-Kinase, Proteomics Laboratory, Washington University School of Medicine , Michael P East, PhD – DRGC-Kinase, Department of Pharmacology, University of North Carolina School of Medicine

11:00-11:30 AM: Break with networking opportunities

11:30-11:45 AM: Introduction to understudied Ion Channels (Michael T. McManus, PhD)

  • 11:45-12:15 PM: “Illuminating the dark channelome” Olga Gulyaeva, PhD – DRGC-Ion Channel, School of Medicine, University of California, San Francisco

12:15-1:15 PM: Lunch with networking opportunities

1:15-1:20 PM:Introduction to Informatics(Tudor Oprea, MD, PhD)

  • 1:20-1:50 PM: “Integration of Biomedical Knowledge Graph Mining and Generative Neural Nets for Drug Discovery” Alexander Tropsha, PhD, Eshelman School of Pharmacy, University of North Carolina
  • 1:50-2:20 PM: “FRASE-bot, an AI-powered Tool for Data-driven Drug Discovery on Orphan Targets” Dmitry Kireev, PhD, Eshelman School of Pharmacy, University of North Carolina
  • 2:20-2:40 PM: “Structure-based deorphanization, and the computational infrastructure that supports it” John Irwin, PhD – DRGC-GPCR, School of Pharmacy, University of California, San Francisco
  • 2:40-3:00 PM: “Data science to illuminate the dark genome” Tudor Oprea, MD, PhD – KMC, RDOC, Translational Informatics Division, University of New Mexico

3:00-3:30 PM: Coffee Break and networking opportunity

3:30-3:45 PM:Introduction to understudied GPCRs(Bryan Roth, MD, PhD)

  • 3:45-4:10 PM: "Insights into ligand mechanisms for “biasing” G protein-coupled receptor signaling” Laura Wingler, PhD, School of Medicine, Duke University
  • 4:10-4:45 PM: “Illuminating the dark GPCR-ome: an integrated approach” Justin English, PhD – DRGC-GPCR, Department of Pharmacology, University of North Carolina, Chapel Hill

4:45-5:00 PM: Wrap-up (Roth, McManus, Johnson)

Dinner TBA at 6:30 PM

Disclaimer note: No Federal funds were spent on food.

In the agenda, speakers from the IDG consortium have been noted to their IDG grant affiliations; DRGC-Data and Resource Generating Center, KMC-Knowledge Management Center, RDOC-Resource Dissemination and Outreach Center, CEIT-Cutting Edge Informatics Tools.