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IDG OUTREACH Meeting UNC      Register Here


IDG outreach meeting at UNC highlighting understudied proteins in three target families (GPCRs, Ion Channels, Kinases) and informatic tools.

About this Event

IDG consortium are partnering together with member groups at UNC to host an open plenary session and an all-day symposium to share their progress on investigating proteins and their impact on diseases and phenotypes. Illuminating the Druggable Genome (IDG) is a NIH founded consortium that aims to highlight new, previously understudied targets within the human genome with the goal of furthering scientific discovery for improving human health. The IDG consortium is made up of experimental groups working in three major protein families: GPCRs, Ion Channels, and Kinases, along with informatics groups managing knowledge and developing tools for improving data analysis and target prioritization.

**Updated March 11, 2020**

In light of the current situation concernign COVID-19, this meeting has been postponed to a later date. The tentative date would be September 10-11, 2020.

Start of the meeting on Thursday, September 10th, is a plenary talk entitled “PKC mutations in disease” given by Alexandra Newton, PhD from the Department of Pharmacology, University of California, San Diego . This plenary session is held in room 1131 in the Bioinformatics Building, UNC, Chapel Hill, NC.

An all-day symposium with speakers from University of North Carolina, Chapel Hill, and Duke University together with Illuminating the Druggable Genome (IDG) members This event will be held in Bondurant Hall G100, UNC, Chapel Hill, NC on Friday September 11, 2020 , 8:30 am to 5 pm.

FAQs

What is the IDG consortium?

The NIH sponsored IDG consortium aims to illuminated understudied targets in three protein families; GPCR, kinase, and ion channels, by producing data and resources via the DRGC, collating and managing whole human proteome knowledge via the KMC, expand outreach of IDG outcomes via RDOC, and developing tools for facilitating data representation by CEITs . Please visit DruggableGenome.net for further information.

Where is the location of these meetings?

Please note there are two different locations. The Plenary session occurring on Thursday, September 10th will take place in room1131 in Bioinformatics Building, UNC, Chapel Hill, NC. The all-symposium on Friday, September 11th, will take place in the Bondurant Hall G100, UNC, Chapel Hill, NC.

Lodging and local transportation options

There is not room block reserved for attendees to this meeting. However here is a list of hotel recommendations in order of proximity to the meeting location:

  • Carolina Inn - link
  • AC Hotel by Marriott - link
  • Franklin Hotel - link
  • Hampton Inn - link
  • Hyatt at Southern Village - link
  • Aloft - link
  • Siena Hotel - link

For information on the free buses in town:

  • Summary of all bus routes - link
  • Individual bus routes - link

How can I contact the organiser with any questions?

Please email idg.rdoc[at]gmail.com

Agenda:

Thursday, September 10 (tentative)

6:00-8:00 PM: PLENARY SESSION with Buffet meal

UNC, Chapel Hill, 1131 Bioinformatics Building

“Protein Kinase C Unbalanced: Loss-of-function vs gain-of-function in disease”

Alexandra Newton, PhD

Department of Pharmacology, University of California, San Diego

Friday, September 11 (tentative)

8:30 AM-5:00 PM: SYMPOSIUM UNC, Chapel Hill, Bondurant Hall G100

8:30-9:00 AM: Breakfast buffet with networking opportunities

9:00-9:15 AM: Welcome (Bryan Roth, MD, PhD)

9:15-9:25 AM: Understudied Kinome Introduction(Gary Johnson, PhD)

  • 9:25-9:50 AM: “Chemoproteomic approaches to accelerate kinase degrader development” Fleur M Ferguson, PhD – DRGC-Kinase, Dana Farber Cancer Institute and Harvard University
  • 9:55-10:30 AM: “Evolutionary clues to dark kinase functions” Natarajan Kannan, PhD – CEIT-UGA, Department of Biochemistry and Molecular Biology, University of Georgia
  • 10:30-11:00 AM: “Functional integration of understudied kinases into established signaling pathways using quantitative omics data” Robert Sprung, PhD – DRGC-Kinase, Proteomics Laboratory, Washington University School of Medicine , Michael P East, PhD – DRGC-Kinase, Department of Pharmacology, University of North Carolina School of Medicine

11:00-11:30 AM: Break with networking opportunities

11:30-11:45 AM: Introduction to understudied Ion Channels (Michael T. McManus, PhD)

  • 11:45-12:15 PM: “Illuminating the dark channelome” Olga Gulyaeva, PhD – DRGC-Ion Channel, School of Medicine, University of California, San Francisco

12:15-1:15 PM: Lunch with networking opportunities

1:15-1:20 PM:Introduction to Informatics(Tudor Oprea, MD, PhD)

  • 1:20-1:50 PM: “Integration of Biomedical Knowledge Graph Mining and Generative Neural Nets for Drug Discovery” Alexander Tropsha, PhD, Eshelman School of Pharmacy, University of North Carolina
  • 1:50-2:20 PM: “FRASE-bot, an AI-powered Tool for Data-driven Drug Discovery on Orphan Targets” Dmitry Kireev, PhD, Eshelman School of Pharmacy, University of North Carolina
  • 2:20-2:40 PM: “Structure-based deorphanization, and the computational infrastructure that supports it” John Irwin, PhD – DRGC-GPCR, School of Pharmacy, University of California, San Francisco
  • 2:40-3:00 PM: “Data science to illuminate the dark genome” Tudor Oprea, MD, PhD – KMC, RDOC, Translational Informatics Division, University of New Mexico

3:00-3:30 PM: Coffee Break and networking opportunity

3:30-3:45 PM:Introduction to understudied GPCRs(Bryan Roth, MD, PhD)

  • 3:45-4:10 PM: "Insights into ligand mechanisms for “biasing” G protein-coupled receptor signaling” Laura Wingler, PhD, School of Medicine, Duke University
  • 4:10-4:45 PM: “Illuminating the dark GPCR-ome: an integrated approach” Justin English, PhD – DRGC-GPCR, Department of Pharmacology, University of North Carolina, Chapel Hill

4:45-5:00 PM: Wrap-up (Roth, McManus, Johnson)

Dinner TBA at 6:30 PM

Disclaimer note: No Federal funds were spent on food.

In the agenda, speakers from the IDG consortium have been noted to their IDG grant affiliations; DRGC-Data and Resource Generating Center, KMC-Knowledge Management Center, RDOC-Resource Dissemination and Outreach Center, CEIT-Cutting Edge Informatics Tools.

**Updated on March 11, 2020: Original schedule of Plenary session on Monday, May 4th and all-day symposium on Tuesday, May 5th has now been postponed until September. Note that these dates of September 10-11, 2020 are tentative.